Integrative Nanophytotherapeutics: Advancing Antimicrobial, Anticancer, And Antidiabetic Applications Through Pomegranate-Derived Nanoparticles and Bioactive Systems
Keywords:
Nanophytotherapy, Pomegranate extract, Silver nanoparticles, Antimicrobial activityAbstract
Nanotechnology has revolutionized therapeutic strategies by enabling targeted delivery, enhanced bioavailability, and controlled release of bioactive compounds. Among natural resources, plant-derived phytochemicals have gained prominence due to their diverse pharmacological properties. This study presents a comprehensive exploration of nanoparticle-based systems synthesized using plant extracts, particularly focusing on pomegranate (Punica granatum) and its derivatives, alongside comparative insights from Carica papaya and Crocus sativus. The article synthesizes evidence on antimicrobial, anticancer, antioxidant, and antidiabetic properties of phytosynthesized nanoparticles and evaluates their integration into modern nanomedicine frameworks. A critical analysis of nanoparticle development challenges, gastrointestinal delivery barriers, and clinical implications is undertaken. The methodology relies on a structured review and integrative theoretical modeling derived strictly from the provided literature. Results indicate that phytosynthesized nanoparticles exhibit enhanced therapeutic efficacy due to synergistic interactions between metallic cores and bioactive phytochemicals. Discussion extends to translational challenges, toxicity concerns, and the need for standardized protocols. The findings underscore the potential of nanophytotherapeutics in addressing global health burdens such as cancer, microbial resistance, and diabetes, while also identifying key research gaps that must be addressed for clinical translation.
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Copyright (c) 2026 Gina Markovic (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
